Interactive Roundtable: Overcoming mRNA-LNP Stability & Storage Challenges to Reduce Cold-Chain Dependence

An interactive discussion bringing together mRNA formulation, analytical and CMC experts to share practical approaches to:

• Improving formulation stability: Comparing liquid formulations, lyophilisation and spray drying to preserve RNA integrity, LNP structure and biological potency
• Extending shelf life & simplifying distribution: Exploring strategies to enable refrigerated (2-8°C) or room-temperature storage while minimising degradation during storage, transport and handling
• Demonstrating stability for clinical translation: Identifying critical stability-indicating attributes, analytical methods and regulatory considerations to establish shelf life and support GMP readiness