Matthias Bozza
Vice President, Strategy & Development CPTx
Matthias Bozza is a company builder, drug developer, and life sciences innovator focused on gene and cell therapy and oncology. Recognized as one of the most talented Italian scientists under 35 in the healthcare sector and a recipient of the Waltraud-Lewenz Award for experimental medicine, Matthias works at the intersection of innovation and therapeutic development. At CPTx, Matthias contributes to advancing programmable DNA medicines and next-generation in vivo therapy platforms.
Seminars
Friday 19th February 2027
Advancing Durable In Vivo CAR-T Cell Engineering Through Non-Viral DNA & mRNA Co-Delivery
1:30 pm
- Optimising co-encapsulation of single-stranded DNA and mRNA within targeted lipid nanoparticles to enable efficient delivery of both nucleic acids into the same cell
- Leveraging single-stranded DNA to address immunogenicity challenges associated with conventional double-stranded DNA delivery while enabling more durable genetic modification
- Demonstrating the flexibility of non-viral genome engineering through site-specific gene integration and multi-gene delivery strategies, supported by preclinical therapeutic data
