Regina Bleul
Head of Nanomedicine Group Fraunhofer ICT-IMM
Dr Regina Bleul is Head of Nanomedicine at Fraunhofer IMM, bringing over 15 years of experience in continuous nanoformulation and advanced drug delivery technologies. She holds a PhD in Macromolecular Chemistry from Freie Universität Berlin.
Her research focuses on developing scalable, modular and automated nanoformulation platforms for therapeutic applications, including mRNA-LNP delivery. Her expertise spans microfluidic formulation, continuous manufacturing, process analytical technologies and nanoparticle characterisation, with a particular focus on improving process efficiency, reproducibility and scalability. She has authored over 20 scientific publications in nanomedicine and nanomaterials research.
Seminars
- Enabling both scale-up for larger production volumes and scale-down for individualised therapies
- Leveraging microtechnology-based tangential flow filtration (TFF) for small-scale RNA and LNP purification and concentration, while minimising particle loss and preserving product quality
- Combining machine learning, predictive modelling and process knowledge to optimise mixing parameters, predict target LNP size and reduce consumption of expensive materials
