Advanced Nanoparticle Characterisation & Tissue-Level Models to Improve Therapeutic Performance

• Evaluating how LNP composition and targeting strategies influence biodistribution, cellular uptake and off-target exposure across preclinical models
• Improving peptide-based nanoparticle activity through formulation optimisation, using cryo-electron microscopy (cryo-EM) to understand particle morphology and structure-activity relationships
• Investigating endosomal escape and cellular trafficking using quantitative livecell microscopy to understand how nanoparticle structure influences transfection efficiency
• Leveraging tissue-on-a-chip models to evaluate nanoparticle penetration, tissue retention and cell-specific transfection before progressing into animal studies

Speakers:

Roland Brock

Professor of Biochemistry, Group Leader Targeted Nanomedicines

Radboud University Medical Center