Advancing Durable In Vivo CAR-T Cell Engineering Through Non-Viral DNA & mRNA Co-Delivery
1:30 pm - Friday 19th February 2027
- Optimising co-encapsulation of single-stranded DNA and mRNA within targeted lipid nanoparticles to enable efficient delivery of both nucleic acids into the same cell
- Leveraging single-stranded DNA to address immunogenicity challenges associated with conventional double-stranded DNA delivery while enabling more durable genetic modification
- Demonstrating the flexibility of non-viral genome engineering through site-specific gene integration and multi-gene delivery strategies, supported by preclinical therapeutic data
