Developing Scalable mRNA-LNP Formulation, Purification & Process Technologies to Accelerate Clinical Translation

• Enabling both scale-up for larger production volumes and scale-down for individualised therapies
• Leveraging microtechnology-based tangential flow filtration (TFF) for small-scale RNA and LNP purification and concentration, while minimising particle loss and preserving product quality
• Combining machine learning, predictive modelling and process knowledge to optimise mixing parameters, predict target LNP size and reduce consumption of expensive materials

Speakers:

Regina Bleul

Head of Nanomedicine Group

Fraunhofer ICT-IMM