Enabling Durable Gene Editing With Transient mRNA Delivery of Editing Machinery
8:30 am - Thursday 18th February 2027
- Engineering compact CRISPR-based gene and epigenetic editors that can be efficiently delivered as mRNA in vivo
- Optimising mRNA architecture and delivery to achieve sufficient intracellular editor expression from a transient dose
- Demonstrating how short-lived editor expression can generate long-lasting gene silencing or therapeutic effects without requiring persistent expression
